Ursodiol does not prevent hepatic venoocclusive disease associated with Mylotarg therapy.

نویسندگان

  • Francis Giles
  • Guillermo Garcia-Manero
  • Jorge Cortes
  • Deborah Thomas
  • Hagop Kantarjian
  • Elihu Estey
چکیده

haematologica vol. 87(10):october 2002 *University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; °Tarbiat Modarres University, School of Medical Sciences, Tehran, Iran; #Department of Clinical Chemistry, Municipal Hospital Rudolfstiftung, Vienna, Austria; @ViennaLab Labordiagnostika GmbH, Vienna, Austria Acknowledgments: we wish to thank A. Moritz, A. Tabarroki, E. Mehdipour, P. Vosough, M. Alebouyeh, Y. Shafaghati, A. HadgFathali, F. Mojtahedzadeh, T. Arzanian, and F. Khoshaiin for their support, and M.H. Karimi-Nejad and D. Farhoud for their assistance in collecting the subjects for this study. Funding: this work was supported by a grant from the Iranian Ministry of Health and Medical Education, Deputy of Research and Technology (contract grant no. 11059). Correspondence: Dr. Hossein Najmabadi, MD, Ph.D., Genetics Research Center, The Social Welfare and Rehabilitation Sciences University, Daneshjoo Blvd., Koodakyar Ave., Evin, Tehran 19834, Iran. Phone/fax: international +98.21.2407814. E-mail: [email protected]

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Gemtuzumab ozogamicin as postconsolidation therapy does not prevent relapse in children with AML: results from NOPHO-AML 2004.

There are no data on the role of postconsolidation therapy with gemtuzumab ozogamicin (GO; Mylotarg) in children with acute myeloid leukemia (AML). The NOPHO-AML 2004 protocol studied postconsolidation randomization to GO or no further therapy. GO was administered at 5 mg/m(2) and repeated after 3 weeks. We randomized 120 patients; 59 to receive GO. Survival was analyzed on an intention-to-trea...

متن کامل

Refractory Ascites with Liver Fibrosis Developed in Late Phase Allogeneic Hematopoietic Stem Cell Transplantation: Report of Three Patients

We report cases of three patients of refractory ascites without other fluid retention that occurred around five months after allogeneic hematopoietic stem cell transplantation (allo-HSCT). All three patients expired and postmortem examinations revealed unexpected liver fibrosis lacking histological evidences of graft-versus-host-disease (GVHD). The three patients showed normal hepatic function ...

متن کامل

Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: in vivo and in vitro saturation and internalization by leukemic and normal myeloid cells.

Antibody-targeted chemotherapy is a promising therapy in patients with acute myeloid leukemia (AML). In a phase II study of Mylotarg (CMA-676, gemtuzumab ozogamicin), which consists of a CD33 antibody linked to calicheamicin, saturation and internalization by leukemic and normal myeloid cells were analyzed in 122 patients with relapsed AML. Peripheral blood samples were obtained just before and...

متن کامل

Liver disease after bone marrow transplantation.

Liver dysfunction occurs after bone marrow transplantation but the relative importance of graft versus host disease and other factors, such as infection, radiation, and drugs, has not been clearly established. We have studied liver status before and after bone marrow transplantation in 43 consecutive patients and have related this to survival and factors that are recognised to cause liver injur...

متن کامل

Ursodeoxycholic acid for the prevention of hepatic complications in allogeneic stem cell transplantation.

The role of ursodeoxycholic acid (UDCA) in the prevention of hepatic complications after allogeneic stem cell transplantation was studied in a prospective randomized open-label multicenter trial. A total of 242 patients were allocated to receive (n = 123) or not to receive (n = 119) UDCA in the dose of 12 mg/kg/d orally from the day preceding the conditioning until day 90 after transplantation....

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Haematologica

دوره 87 10  شماره 

صفحات  -

تاریخ انتشار 2002